Glasgow is the largest city in Scotland, and the third largest in the United Kingdom. At the 2011 census, it had a population density of 3,395 people per square kilometre, the highest of any Scottish city. It is situated on the River Clyde in the country's West Central Lowlands. Inhabitants of the city are referred to as Glaswegians.Glasgow grew from a small rural settlement on the River Clyde to become one of the largest seaports in Britain. Expanding from the medieval bishopric and royal burgh, and the later establishment of the University of Glasgow in the 15th century, it became a major centre of the Scottish Enlightenment in the 18th century. From the 18th century the city also grew as one of Great Britain's main hubs of transatlantic trade with North America and the West Indies.With the onset of the Industrial Revolution, the population and economy of Glasgow and the surrounding region expanded rapidly to become one of the world's pre-eminent centres of chemicals, textiles and engineering; most notably in the shipbuilding and marine engineering industry, which produced many innovative and famous vessels. Glasgow was the "Second City of the British Empire" for much of the Victorian era and Edwardian period although many cities argue the title was theirs. Today it is one of Europe's top ten financial centres and is home to many of Scotland's leading businesses. Glasgow is also ranked as the 57th most liveable city in the world.