Greensboro is a city in the U.S. state of North Carolina. It is the third-largest city by population in North Carolina and the largest city in Guilford County and the surrounding Piedmont Triad metropolitan region. According to the 2012 U.S. Census Estimate, Greensboro's population is 277,080. It is located at the intersection of three major interstate highways in the Piedmont region of central North Carolina.In 2003, the previous Greensboro – Winston-Salem – High Point metropolitan statistical area was re-defined by the U.S. Office of Management and Budget, resulting in the formation of the Greensboro-High Point MSA and the Winston-Salem MSA. The 2010 population for the Greensboro-High Point MSA was 723,801. The Greensboro – Winston-Salem – High Point combined statistical area , popularly referred to as the Piedmont Triad, had a population of 1,599,477.In 1808, Greensborough was planned around a central courthouse square to succeed the nearby town of Guilford Court House as the county seat. This act moved the county courts closer to the geographical center of the county, a location more easily reached by the majority of the county's citizens.