at Wellcome Trust-Medical Research Council Stem Cell Institute University of Cambridge Clifford; Allbutt Building - Cambridge Biosciences Campus, Cambridge, CB2 0HA United Kingdom
A group of young, curious and enthusiastic experimentalists dreaming to repair the injured brain. We practice the principle of think FAST, work FASTER!!
The development of cell-based therapies aimed to promote tissue repair in central nervous system (CNS) diseases, represents one of the most challenging areas of investigation in the field of regenerative medicine. Several cell-replacement strategies have been developed in the last few years. Recent evidence from our own and other laboratories indicates that undifferentiated neural stem/precursor cells (NPCs) might very efficiently protect the CNS from chronic degeneration induced by inflammation both in small rodents as well as in primates. However, before envisaging any potential human applications of such innovative therapies we need to confront with some preliminary and still unsolved questions: 1. The ideal stem cell source for transplantation, whether it has to be from pluripotent or multipotent sources; 2. The ideal route of cell administration, whether it has to be focal or systemic; 3. The ideal balance between differentiation and persistence of stem cells into the targeted tissue and – last but not least – 4. The ideal mechanism of tissue repair to foster, whether it has to be cell replacement or tissue protection (rescue). Current projects in our laboratory are further exploring the cellular and molecular mechanisms regulating the therapeutic plasticity of NPCs in complex CNS diseases such as multiple sclerosis, and spinal cord injury
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