Union Station in San Diego, California, much more commonly known as the Santa Fe Depot, is a train station built by the Atchison, Topeka and Santa Fe Railway to replace the small Victorian-style structure erected in 1887 for the California Southern Railroad Company. The Spanish Colonial Revival style station is listed on the National Register of Historic Places. Its architecture, particularly the signature twin domes, is often echoed in the design of modern buildings in Downtown San Diego. A wing now houses the downtown branch of the Museum of Contemporary Art San Diego.The Santa Fe Depot (as it was originally designated) officially opened on March 8, 1915, to accommodate visitors to the Panama-California Exposition. The depot was completed during a particularly optimistic period in the City's development, and represents the battle waged by the City of San Diego to become the West Coast terminus of the Santa Fe Railway system’s transcontinental railroad, a fight that was ultimately lost to the City of Los Angeles.

Fifth Avenue is a station of the Blue, Orange, and Silver Lines on the San Diego Trolley. It is located in the Downtown Core of the city and is surrounded by a variety of important office buildings.Upon the opening of the San Diego Trolley service in 1981, this station on C Street, between Sixth Avenue and Fifth Avenue, was originally named the Gaslamp North station or the Centre City station. In 1986, the station was permanently renamed the Fifth Avenue Station.This station was closed on December 17, 2012, for renovations as part of the Trolley Renewal Project. It was reopened by June of 2013, and is now back to normal operations.See also List of San Diego Trolley stations