The Diocese of Fort Wayne–South Bend is a Roman Catholic diocese in north-central and northeastern Indiana. The Most Reverend Kevin C. Rhoades was appointed diocesan bishop by Pope Benedict XVI on November 14, 2009, and was installed on January 13, 2010. The Diocese of Fort Wayne–South Bend encompasses 14 Indiana counties: Adams, Allen, DeKalb, Elkhart, Huntington, Kosciusko, LaGrange, Marshall, Noble, Steuben, St. Joseph, Wabash, Wells, and Whitley. The diocese has a co-cathedral setup with the Cathedral of the Immaculate Conception in Fort Wayne as the primary cathedral and Saint Matthew's Cathedral in South Bend as the associate cathedral.

The Fort Wayne Old City Hall Building in downtown Fort Wayne, Indiana operates as a museum known as The History Center, and has served as headquarters for the Allen County–Fort Wayne Historical Society since 1980. The Richardsonian Romanesque style sandstone building was designed by the noted architectural firm Wing & Mahurin and built in 1893. It served as a functioning city hall for the city until 1971 when local officials moved to the City-County Building.It was listed on the National Register of Historic Places in 1973.The History Center has collected 27,000 artifacts in permanent displays dedicated to the region's history, dating from the Ice Age to the 18th century to present.The Society also owns the National Historic Landmark Chief Jean Baptiste de Richardville House.

Fort Wayne in modern Fort Wayne, Indiana, was established by Captain Jean François Hamtramck under orders from General "Mad" Anthony Wayne as part of the campaign against the Indians of the area. It was named after General Wayne, who was victorious at the Battle of Fallen Timbers. Wayne may have chosen the name himself—the fort was dedicated the day after he left it. The fort was officially occupied by the army on October 21, 1794. The fort was a basic stockade with few buildings, and was located near the present intersection of Berry and Clay streets.HistoryFort Wayne was the successor of several previous military outposts at the location. Jean Baptiste Bissot, Sieur de Vincennes built the first fortified trading post on the site in 1704 called Fort Miami.Fort WayneWayne's Legion arrived at Kekionga on 17 September 1794, and Wayne personally selected the site for the new U.S. fort. Wayne wanted a strong fort built, capable of withstanding not only an Indian uprising, but a possible attack by the British from Fort Detroit. The fort was finished by 17 October, and was capable of withstanding 24-pound cannons. It was named Fort Wayne and placed under command of Major Jean François Hamtramck, who had been commandant of Fort Knox in Vincennes. The fort was officially dedicated 22 October (the fourth anniversary of Harmar's Defeat), and the day is considered the founding of the modern city of Fort Wayne.